| 摘要 |
<p>Injections for an eye tissues which contain a drug covalently bound to PEG. When a drug bound to PEG is injected into an eye tissue (iridociliary body, vitreous body, retina, optic nerve, etc.), the drug can be sustained in the tissue over a long time. Thus, the above injection makes it possible to treat or prevent various diseases in eye tissues by a single administration. PEG may be either in the chain-, star- or branched type. In case of chain-type PEG, a drug is generally bound using hydroxyl groups at both ends. Thus, the binding ratio of the drug to PEG is 1:1 or 2:1. In case of star- or branched-type PEG having a plural number of hydroxyl groups, a plural number of drugs can be covalently bound thereto.</p> |
