发明名称 |
TIMED, SUSTAINED RELEASE MULTI-PARTICULATE DOSAGE FORMS OF PROPRANOLOL |
摘要 |
A unit dosage form, such as a capsule or the like for delivering drugs into the body in a circadian release fashion, is comprising of one or more population of propranolol-containing particles (beads, pellets, granules, etc.). Each bead population exhibits a predesigned rapid or sustained releas e profile with or without a predetermined lag time of 3 to 5 hours. Such a circadian rhythm release cardiovascular drug delivery system is designed to provide a plasma concentration - time profile, which varies according to physiological need during the day, i.e., mimicking the circadian rhythm and severity manifestation of a cardiovascular disease, prodicted based on pharmaco-kinetic and pharmaco-dynamic considerations and in vitro/in vivo correlations.
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申请公布号 |
CA2462637(A1) |
申请公布日期 |
2003.04.10 |
申请号 |
CA20022462637 |
申请日期 |
2002.10.02 |
申请人 |
EURAND PHARMACEUTICALS LTD. |
发明人 |
VISHNUPAD, KRISHNA S.;PERCEL, PHILLIP J.;VENKATESH, GOPI M. |
分类号 |
A61K9/14;A61K9/50;A61K9/52;A61K9/54;A61K9/62;A61K31/138;A61K47/14;A61K47/32;A61K47/34;A61K47/38;A61K47/44;A61P9/00;(IPC1-7):A61K9/62 |
主分类号 |
A61K9/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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