PRODRUGS OF SUBSTITUTED POLYCYCLIC COMPOUNDS USEFUL FOR SELECTIVE INHIBITION OF THE COAGULATION CASCADE,申请号WO2002US31468-传众专利搜索

发明名称	PRODRUGS OF SUBSTITUTED POLYCYCLIC COMPOUNDS USEFUL FOR SELECTIVE INHIBITION OF THE COAGULATION CASCADE
摘要	The present invention relates to prodrug compounds, comprising a 5- or 6- membered heterocyclic or aromatic ring substituted with a derivatized amidine, as well as compositions and methods useful for preventing and treating thrombotic conditions in mammals. The prodrug compounds of the present invention selectively inhibit certain proteases of the coagulation cascade.
申请公布号	WO03028729(A2)	申请公布日期	2003.04.10
申请号	WO2002US31468	申请日期	2002.10.03
申请人	PHARMACIA CORPORATION;SOUTH, MICHAEL, S.;WEBBER, RONALD, K.;HUANG, HORNG-CHIH;TOTH, MIHALY, V.;MOORMANN, ALAN, E.;SNYDER, JEFFREY, S.;SCHOLTEN, JEFFREY, A.;GARLAND, DANNY, J.;RUEPPEL, MELVIN, L.;NEUMANN, WILLIAM, L.;LONG, SCOTT;WEI, HUANG;TRUJILLO, JOHN;PARLOW, JOHN, J.;JONES, DARIN, E.;CASE, BRENDA;HAYES, MICHAEL, J.;ZENG, QINGPING	发明人	SOUTH, MICHAEL, S.;WEBBER, RONALD, K.;HUANG, HORNG-CHIH;TOTH, MIHALY, V.;MOORMANN, ALAN, E.;SNYDER, JEFFREY, S.;SCHOLTEN, JEFFREY, A.;GARLAND, DANNY, J.;RUEPPEL, MELVIN, L.;NEUMANN, WILLIAM, L.;LONG, SCOTT;WEI, HUANG;TRUJILLO, JOHN;PARLOW, JOHN, J.;JONES, DARIN, E.;CASE, BRENDA;HAYES, MICHAEL, J.;ZENG, QINGPING
分类号	A61K31/4375;A61K31/4965;A61K31/497;A61K31/4985;A61K31/536;A61K31/5377;A61K45/00;A61P7/02;A61P9/00;A61P11/00;A61P43/00;C07C257/18;C07D207/32;C07D211/56;C07D211/98;C07D213/74;C07D231/38;C07D231/48;C07D237/04;C07D239/10;C07D239/22;C07D241/04;C07D241/20;C07D249/14;C07D253/06;C07D253/075;C07D263/48;C07D265/02;C07D277/42;C07D307/22;C07D333/36;C07D401/12;C07D403/10;C07D405/12;C07D409/12;C07D413/12;C07D417/12;C07D471/04	主分类号	A61K31/4375
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