发明名称 |
PHENYLPYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME |
摘要 |
<p>Phenylpyridazine compounds represented by the following formula (I): <CHEM> (wherein R1 represents a substituted or unsubstituted phenyl or a a substituted or unsubstituted pyridyl; R2 represents a lower alkoxy group, a lower alkylthio group, a lower alkylsufinyl group or a lower alkylsulfonyl group; R3 represents a hydrogen atom or a lower alkoxy group; and R4 represents a hydrogen atom or a substituted alkyl group), are provided having excellent inhibitory activity against interleukin-1 beta production, and useful in the treatment of prevention of diseases caused by stimulation of interleukin-1 beta production, such as immune system diseases, inflammatory diseases, and ischemic diseases.</p> |
申请公布号 |
EP1300399(A1) |
申请公布日期 |
2003.04.09 |
申请号 |
EP20010947902 |
申请日期 |
2001.07.06 |
申请人 |
KOWA CO., LTD. |
发明人 |
OHKUCHI, MASAO;KYOTANI, YOSHINORI;SHIGYO, HIROMICHI;KOSHI, TOMOYUKI;OHGIYA, TADAAKI;MATSUDA, TAKAYUKI;KUMAI, NATSUYO;YASUOKA, KYOKO |
分类号 |
A61K31/50;A61P9/10;A61P19/10;A61P29/00;C07D237/08;C07D237/12;C07D237/14;C07D237/18;C07D237/20;C07D237/24;C07D401/12;C07D405/04;C07D417/04;(IPC1-7):A61K31/50;C07D401/04;A61P19/02 |
主分类号 |
A61K31/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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