发明名称 |
METHOD FOR MICROBIALLY PRODUCING L-VALINE |
摘要 |
The present invention relates to a process for the microbial production of L-valine in which the dihydroxy acid-synthase (ilvD) activity and/or the ilvD gene expression is intensified in a microorganism. As an alternative or in combination with this, the acetohydroxy acid-synthase (ilvBN) activity and isomeroreductase (ilvC) activity and/or the ilvBNC gene expression are intensified in a microorganism. The process according to the invention preferably makes use of microorganisms in which the activity of at least one enzyme that is involved in a metabolic pathway that reduces the formation of L-valine is weakened or eliminated. Thus, for instance, the process according to the invention preferably makes use of microorganisms having a defect mutation in the threonine dehydratase (ilvA) gene and/or a defect mutation in one or more genes of the pantothenate synthesis. |
申请公布号 |
EP1155139(B1) |
申请公布日期 |
2003.04.09 |
申请号 |
EP20000906363 |
申请日期 |
2000.02.21 |
申请人 |
FORSCHUNGSZENTRUM JUELICH GMBH |
发明人 |
EGGELING, LOTHAR;SAHM, HERMANN |
分类号 |
C12N1/21;C12N9/00;C12N9/10;C12N9/88;C12P13/06 |
主分类号 |
C12N1/21 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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