Substituted indolinones with kinase inhibitory activity

摘要

Substituted indolinones of general formulahaving effect on various kinases and cycline/CDK complexes and on the proliferation of various tumour cells. Exemplary compounds are:3-Z-[1-(4-(N-Benzyl-N-methyl-aminomethyl)-phenylamino)-1-methyl-methylene]-5-amido-2-indolinone and3-Z-[1-(4-(2,3,4,5-Tetrahydro-benzo(d)azepin-3-yl-methyl)-phenylamino)-1-methyl-methylene]-5-amido-2-indolinone.