| 发明名称 |
Non-defective Epstein-Barr viral vector |
| 摘要 |
The present invention relates to a viral vector system derived from Epstein-Barr Virus (EBV), where the transgene is effectively inserted into the EBV major internal repeat region (IR1) without adverse affect on EBV latent or lytic function. The vector of the invention can target and stably transform B-lymphocyte cells, both in culture and in vivo.
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| 申请公布号 |
US6544781(B1) |
申请公布日期 |
2003.04.08 |
| 申请号 |
US20000617800 |
申请日期 |
2000.07.17 |
| 申请人 |
THE GENERAL HOSPITAL CORPORATION |
发明人 |
JIANG XIAOQUN;CHIOCCA E. ANTONIO;KIEFF ELLIOTT;WANG FRED;HOCHBERG FRED |
| 分类号 |
A61K48/00;C12N15/869;(IPC1-7):C12N15/00;C12N15/09;C12N15/63;C12N15/70;C12N15/74 |
主分类号 |
A61K48/00 |
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