发明名称 |
Compositions and methods of treating cancer using compositions comprising an inhibitor or endothelin receptor activity |
摘要 |
Described herein are results which show that an endothelin receptor antagonist, BQ788, increases pigmentation and significantly reduces the viability of 7 human melanoma cell lines in culture. Moreover, it is described herein that administration of BQ788 significantly slows melanoma tumor growth in nude mice, including a complete growth arrest in half of the mice treated systemically. Thus, inhibitors of endothelin receptor activity are described herein as beneficial for the treatment of cancer.
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申请公布号 |
US6545048(B1) |
申请公布日期 |
2003.04.08 |
申请号 |
US19990404626 |
申请日期 |
1999.09.23 |
申请人 |
CALIFORNIA INSTITUTE OF TECHNOLOGY |
发明人 |
PATTERSON PAUL H.;LAHAV RONIT |
分类号 |
A61K38/06;A61K38/22;A61K47/48;A61P35/00;(IPC1-7):A61K31/195 |
主分类号 |
A61K38/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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