Fremgangsmåde til fremstilling af mellemprodukter til syntese af antifungale midler

摘要

A process for producing a crystalline chiral hydroxy ester of formula (1.0) is disclosed. The process comprises reacting a diol of formula (2.0), with an effective amount of isobutyric anhydride and an effective amount of a lipase enzyme in an effective amount of acetonitrile, said reaction being conducted at a low temperature, and wherein X<1> and X<2> are each independently selected from F or Cl.