发明名称 |
Method of inhibiting PTP 1B and /or T-cell PTP and/or other PTPases with an Asp residue at position 48 |
摘要 |
This invention relates to oxalylamide inhibitors of Protein Tyrosine Phosphatase 1B (PTP1B) and/or T-cell Protein Tyrosine Phosphatase (TC-PTP) and/or Protein Tyrosine Phosphatases (PTPases) having an aspartic acid (Asp) in position 48 (PTP1B numbering, Chernoff et al, Proc Natl Acad Sci USA 87: 2735-2789 (1989)) and a method of inhibiting such PTPases by exposing the enzyme to inhibitor compounds of formula 1 This invention also relates to (I) the design and selection of inhibitors, which bind to the active site of PTP1B and/or TC-PTP and/or PTPases having an aspartic acid (Asp) in position 48 (II) the synthesis of said inhibitors, methods for their preparation and (III) to compositions comprising the inhibitor compounds.
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申请公布号 |
US2003064979(A1) |
申请公布日期 |
2003.04.03 |
申请号 |
US20020185901 |
申请日期 |
2002.06.27 |
申请人 |
HANSEN THOMAS KRUSE;OLSEN OLE HVILSTED;PETERSEN ANDERS KLARSKOV;LAU JESPER;ANDERSEN HENRIK SUNE;MOLLER NIELS PETER HUNDAHL |
发明人 |
HANSEN THOMAS KRUSE;OLSEN OLE HVILSTED;PETERSEN ANDERS KLARSKOV;LAU JESPER;ANDERSEN HENRIK SUNE;MOLLER NIELS PETER HUNDAHL |
分类号 |
C07D495/18;C07D498/18;(IPC1-7):A61K31/551;C07D487/12 |
主分类号 |
C07D495/18 |
代理机构 |
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