ANTISENSE MODULATION OF ACYL COA CHOLESTEROL ACYLTRANSFERASE-2 EXPRESSION
摘要
Antisense compounds, compositions and methods are provided for modulating the expression of acyl CoA cholesterol acyltransferase-2. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding acyl CoA cholesterol acyltransferase-2. Methods of using these compounds for modulation of acyl CoA cholesterol acyltransferase-2 expression and for treatment of diseases associated with expression of acyl CoA cholesterol acyltransferase-2 are provided.
申请公布号
WO03011889(A3)
申请公布日期
2003.04.03
申请号
WO2002US22746
申请日期
2002.07.15
申请人
ISIS PHARMACEUTICALS, INC.;CROOKE, ROSANNE, M.;GRAHAM, MARK, J.;LEMONIDIS, KRISTINA, M.
发明人
CROOKE, ROSANNE, M.;GRAHAM, MARK, J.;LEMONIDIS, KRISTINA, M.