METHODS OF GROWING CRYSTALS OF FREE, ANTIBIOTIC-COMPLEXED, AND SUBSTRATE-COMPLEXED LARGE RIBOSOMAL SUBUNITS, AND METHODS OF RATIONALLY DESIGNING OR IDENTIFYING ANTIBIOTICS USING STRUCTURE COORDINATE DATA DERIVED FROM SUCH CRYSTALS

摘要

Methods of growing crystals of free, antibiotic complexed, or ribosomal substrate complexed large ribosomal subunits, coordinates defining the three-dimensional atomic structure thereof and methods of utilizing such coordinates for rational design or identification of antibiotics or large ribosomal subunits having desired characteristics are disclosed.