发明名称 |
SUBSTITUTED 3-PYRIDYL INDOLES AND INDAZOLES AS C17,20 LYASE INHIBITORS |
摘要 |
The invention provides novel substituted 3-pyridyl indoles and indazoles and pharmaceutical compositions thereof. The invention also provides methods of use of substituted 3-pyridyl indoles and indazoles and pharmaceutical compositions thereof as inhibitors of lyases, e.g., the 17 alpha -hydroxylase-C17,20-lyase enzyme. The invention further provides methods for the treatment of cancer in a subject, comprising administering a substituted 3-pyridyl indoles and indazoles or a pharmaceutical composition comprising a substituted 3-pyridyl indoles and indazoles to a subject. The cancer can be, e.g., prostate cancer or breast cancer. |
申请公布号 |
WO03027094(A2) |
申请公布日期 |
2003.04.03 |
申请号 |
WO2002US30482 |
申请日期 |
2002.09.26 |
申请人 |
BAYER CORPORATION;LADOUCEUR, GAETAN, H.;BURKE, MICHAEL, J.;WONG, WAI, C.;BIERER, DONALD |
发明人 |
LADOUCEUR, GAETAN, H.;BURKE, MICHAEL, J.;WONG, WAI, C.;BIERER, DONALD |
分类号 |
C07D401/04;A61K31/4439;A61K31/444;A61K31/4545;A61K31/4709;A61K31/4725;A61K31/496;A61K31/497;A61K31/506;A61K31/519;A61K31/5377;A61P5/38;A61P9/12;A61P13/08;A61P15/00;A61P31/10;A61P35/00;A61P43/00;C07D401/14;C07D405/14;C07D409/14;C07D413/04;C07D413/14;C07D417/04;C07D417/06;C07D417/14;C07D513/04 |
主分类号 |
C07D401/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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