In one embodiment, a dosage form comprises: (a) at least one active ingredient; (b) a molded core which is solid at room temperature; and (c) a shell which is in contact with at least a portion of the core, wherein the dosage form provides modified release of the active ingredient upon contacting of the dosage form with a liquid medium. In another embodiment of this invention, a dosage form comprises: (a) at least one active ingredient; (b) a molded core comprising a plurality of particles; and (c) a shell which is in contact with at least a portion of the core, wherein the dosage form provides modified release of the active ingredient upon contacting of the dosage form with a liquid medium.
申请公布号
WO03026615(A2)
申请公布日期
2003.04.03
申请号
WO2002US31116
申请日期
2002.09.28
申请人
MCNEIL-PPC, INC.;LEE, DER-YANG;LI, SHUN-POR;PARIKH, NARENDRA;MCTEIGUE, DAN;SOWDEN, HARRY, S.;THOMAS, MARTIN;WYNN, DAVID
发明人
LEE, DER-YANG;LI, SHUN-POR;PARIKH, NARENDRA;MCTEIGUE, DAN;SOWDEN, HARRY, S.;THOMAS, MARTIN;WYNN, DAVID