CONVERSION OF RED BLOOD CELLS A, B, AND AB USING A-N-ACETYLGALACTOSAMINIDASES AND A-GALACTOSIDASE

摘要

This invention relates to enzymatic removal of type A and B antigens from blood group A, B, and AB reactive cells in blood products, and thereby converting these to non-A and non-B reactive cells. The invention further relates to using unique a-N-acetylgalactosaminidases and a-galactosidases wi th superior kinetic properties for removing the immunodominant monosaccharides of the blood group A and B antigens and improved performance in enzymatic conversion of red blood cells.