发明名称 |
ANTI-FUSION ASSAY |
摘要 |
Methods of identifying a fusion inhibitor and inhibitors of gp41-mediated membrane fusion are disclosed. The methods comprise, for example, providing a first helical polypeptide comprising a sequence of IQN17 (SEQ ID NO: 1); providing a second helical polypeptide of 34 or less than 34 amino acids comprising the amino acid sequence W-X1-X2-W-X3-X4-X5-I, wherein X1, X2, X3, X4, and X5 are each independently chosen from any amino acid except proline; measuring, by capillary zone electrophoresis, the degree of complex formation between these peptides; and comparing the measured degree of complex formation to the degree in the presence of a test composition. |
申请公布号 |
WO03027255(A2) |
申请公布日期 |
2003.04.03 |
申请号 |
WO2002US30611 |
申请日期 |
2002.09.27 |
申请人 |
TIBOTEC PHARMACEUTICALS LTD.;XIE, DONG;ERICKSON, JOHN, W.;GRULICH, PAUL |
发明人 |
XIE, DONG;ERICKSON, JOHN, W.;GRULICH, PAUL |
分类号 |
A61K45/00;A61P31/18;C07K7/00;C07K14/47;G01N27/447;G01N33/15;G01N33/48;G01N33/50;G01N33/561;G01N33/569;G01N33/68;G06F19/00 |
主分类号 |
A61K45/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|