| 摘要 |
<p>The present invention comprises reagents and methods which target actin filaments or the cellular signals that control actin filament integrity. Specifically, the invention provides novel actin binding polypeptides (e.g., human AFAP polypeptides), antibodies which specifically recognize the same, nucleic acids encoding the same, and methods for using these polypeptides, antibodies, and nucleic acids. Such reagents are useful for the diagnosis, prognosis and treatment of cancer, and in the research and development of anti-cancer diagnostic and therapeutic agents. Such reagents are useful for treatment of conditions associated with aberrant angiogenesis, for example, obesity. In one aspect, model animals are provided comprising AFAP regulatory sequences operably linked to reporter molecules. These animals provide a system in which to study the affect of agents on neural development.</p> |
