发明名称 METHOD AND PHARMACEUTICAL COMPOSITION FOR INDUCING CANCER CELL-SPECIFIC APOPTOSIS BY COMBINATION WITH TNF FAMILY PROTEINS AND FLAVOPIRIDOL
摘要 <p>The present invention relates to a cancer cell- specific apoptosis inducing composition. The TNF (tumor necrosis factor; hereinafter, referred to as ' TNF ') family proteins and flavopiridol (also its salts) and the like are individually disadvantageous to provoke a serious side effect such as toxicity against an excessive dose, although they have excellent anti-cancer effects respectively. The composition of the present invention is prepared by combining the TNF family protein and flavopiridol, which reduces the toxicity or the side effect induced during the independent treatment at an high concentration, since the TNF family protein and flavopiridol are blended at an low concentration. Also, the composition has a specific action for cancer cells and a synergistic efficacy pharmaceutically.</p>
申请公布号 WO2003028001(A2) 申请公布日期 2003.04.03
申请号 KR2002001780 申请日期 2002.09.19
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