-AMINOALCOHOL COMPOUND SUBSTITUTED WITH PHENYLTETRAZOLE DERIVATIVE

摘要

PURPOSE: Provided are β-aminoalcohol compound substituted with phenyltetrazole derivative, its pharmaceutically acceptable salt, a manufacturing method thereof, and a pharmaceutical composition containing the same. The β-aminoalcohol derivative reduces blood sugar level and a body weight and is thus used as a therapeutic agent for obesity. It also increases HDL cholesterol level and triglyceride level to treat and prevent atherosclerosis. CONSTITUTION: The β-aminoalcohol compound substituted with phenyltetrazole derivative is represented by the formula(I) is manufactured characteristically by; condensation reaction of phenyltetrazole substituted ketone compound of the formula(II) and β-aminoalcohol compound of the formula(III) with addition of hydrogen under the presence of organometal catalyst. The formula(I) is as defined in the specification.