发明名称 |
1H-IMIDAZOLE DERIVATIVES HAVING CB1 AGONISTIC, CB1 PARTIAL AGONISTIC OR CB1- ANTAGONISTIC ACTIVITY |
摘要 |
The present invention relates to a group of novel 1H-imidazole derivatives, to methods for the preparation of these compounds, and to pharmaceutical compositions containing one or more of these compounds as an active component.These 1H-imidazole derivatives are potent cannabinoid-CB1 receptor agonists, partial agonists or antagonists, useful for the treatment of psychiatric and neurological disorders, as well as and other diseases involving cannabinoid neurotransmission.The compounds have the general formu la (I) wherein R and R1-R4 have the meanings given in the specification.</SDOAB >
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申请公布号 |
CA2457444(A1) |
申请公布日期 |
2003.04.03 |
申请号 |
CA20022457444 |
申请日期 |
2002.09.17 |
申请人 |
SOLVAY PHARMACEUTICALS B.V. |
发明人 |
HERREMANS, ARNOLDUS H.J.;LANGE, JOSEPHUS H.M.;KRUSE, CORNELIS G.;VAN STUIVENBERG, HERMAN H. |
分类号 |
A61K31/4164;A61K31/4178;A61K31/4439;A61K31/454;A61K31/4545;A61K31/4725;A61K31/5377;A61K31/55;A61P1/04;A61P1/08;A61P1/12;A61P3/04;A61P3/10;A61P9/10;A61P11/00;A61P11/06;A61P25/00;A61P25/02;A61P25/04;A61P25/08;A61P25/14;A61P25/16;A61P25/18;A61P25/22;A61P25/24;A61P25/28;A61P25/30;A61P27/06;A61P31/04;A61P35/00;A61P43/00;C07C257/18;C07D233/90;C07D295/30;C07D401/04;C07D401/06;C07D403/04;C07D403/12;C07D405/04;C07D405/12;(IPC1-7):C07D403/12;A61K31/416 |
主分类号 |
A61K31/4164 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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