发明名称 |
POLYAMINO PARAMAGNETIC CHELATES WHICH CONTAIN BOTH PHOSPHONATE AND NON-PHOSPHONATE MOIETIES FOR MRI |
摘要 |
<p>Ligands with three or more nitrogen atoms incorporated into a linear or cyclic backbone structure, with the nitrogen atoms substituted with a combination of phosphonate groups and nonphosphonate groups, of which at least two are phosphonate groups, are disclosed. These ligands are combined with paramagnetic metal cations and administered in the form of pharmacologically acceptable salts, are useful as MRI contrast enhancement agents, which tend to localize in bone tissue without being conjugated to bone-specific biomolecules. Triazacyclononanes and tetraazacyclododecanes, with dihydroxyphosphorylmethyl or dihydroxyphosphorylethyl groups linked to the backbone nitrogens are preferred.</p> |
申请公布号 |
EP0717639(B1) |
申请公布日期 |
2003.04.02 |
申请号 |
EP19940922745 |
申请日期 |
1994.07.28 |
申请人 |
CHELATOR LLC |
发明人 |
WINCHELL, HARRY, S.;KLEIN, JOSEPH, Y.;CYJON, ROSA, L.;SIMHON, ELLIOT, D. |
分类号 |
G01R33/28;A61B5/055;A61K49/00;A61K49/06;C07F9/6515;C07F9/6524;C09K3/00;(IPC1-7):A61K49/00;C07D225/00;C07D225/02;C07F9/651;C07F9/652 |
主分类号 |
G01R33/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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