| 发明名称 |
FUSED IMIDAZOLIUM DERIVATIVES |
| 摘要 |
This invention relates to medicaments, particularly novel fused imidazolium derivatives useful for the treatment of cancers and novel synthetic intermediate compounds thereof. The novel imidazolium derivatives fused with an aryl or heteroaryl ring, characterized in that the 1- and/or 3-position is substituted by an alkyl group etc. having a substituent selected from the group consisting of -ORa, -SRa and the like, have excellent anti-tumor activity and low toxicity and are useful as anticancer agents having wide margins of safety. <CHEM> |
| 申请公布号 |
EP1256576(A4) |
申请公布日期 |
2003.04.02 |
| 申请号 |
EP20010904433 |
申请日期 |
2001.02.14 |
| 申请人 |
YAMANOUCHI PHARMACEUTICAL CO. LTD. |
发明人 |
MATSUHISA, AKIRA;KINOYAMA, ISAO;TOYOSHIMA, AKIRA;NAKAHARA, TAKAHITO;TAKEUCHI, MASAHIRO;OKADA, MINORU |
| 分类号 |
A61K31/36;A61K31/416;A61K31/4188;A61K31/424;A61K31/4245;A61K31/427;A61K31/429;A61K31/437;A61K31/4453;A61K31/4468;A61K31/454;A61K31/47;A61K31/4709;A61K31/497;A61K31/4985;A61K31/501;A61K31/5025;A61K31/506;A61K31/519;A61K31/5375;A61K31/551;A61P35/00;C07C233/41;C07C235/14;C07C237/04;C07C255/24;C07C255/25;C07C255/58;C07C259/06;C07C271/28;C07C311/37;C07C317/28;C07C323/25;C07D209/16;C07D211/58;C07D213/38;C07D213/64;C07D213/74;C07D213/89;C07D215/12;C07D233/54;C07D235/02;C07D235/10;C07D235/14;C07D239/26;C07D241/12;C07D241/20;C07D295/13;C07D307/14;C07D317/58;C07D333/68;C07D335/06;C07D401/04;C07D401/06;C07D401/12;C07D401/14;C07D403/06;C07D403/14;C07D405/06;C07D471/04;C07D491/048;C07D495/04;C07D498/04 |
主分类号 |
A61K31/36 |
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