发明名称 |
N-terminally truncated HER-2/neu protein as a cancer prognostic indicator |
摘要 |
There is disclosed an initial identification of an N-terminally truncated HER-2/neu product. This product is a 95 kDa polypeptide having in vitro kinase activity (as determined by western blotting). Moreover, immunoprecipitations using domain specific antibodies was able to utilize this specific polypeptide from intracellular fragments as a diagnostic and prognostic indicator of adenomacarcinomas without the severe dilution effects encountered by measuring ECD.
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申请公布号 |
US6541214(B1) |
申请公布日期 |
2003.04.01 |
申请号 |
US19980192206 |
申请日期 |
1998.11.13 |
申请人 |
OREGON HEATH SCIENCE UNIVERSITY |
发明人 |
CLINTON GAIL M. |
分类号 |
G01N33/53;A61K38/00;A61K39/395;A61P35/00;C12Q1/48;G01N33/15;G01N33/50;G01N33/566;G01N33/574;G01N33/577;(IPC1-7):G01N33/574;G01N33/567;G01N33/543;C07K2/00 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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