| 摘要 |
Novel, orally active androgens are 7alpha-substituted DELTA14-nandrolone derivatives. The compounds satisfy the general formula:whereinR1 is O, (H,H), (H,OR), NOR, with R being hydrogen, (C1-6) alkyl, or (C1-6) acyl;R2 is selected from the group consisting of (C2-4) alkyl, (C2-4) alkenyl, or (C2-4) alkynyl, each optionally substituted by halogen; orR2 is cyclopropyl, or cyclopropenyl, each optionally substituted by (C1-2) alkyl, or halogen;R3 is hydrogen, (C1-2) alkyl, or ethenyl;R4 is (C1-2) alkyl;R5 is hydrogen, or (C1-15) acyl;and the dotted lines indicate optional bonds.
|
