发明名称 |
Prophylactic use of n-methyl-d-asparrate (NMDA) antagonists. |
摘要 |
This invention provides a method of inhibiting in a mammal neurological damage resulting from impairment of glucose and/or oxygen supply to the brain, which method comprises administering to the mammal prior to the impairment of glucose and/or oxygen supply to the brain an amount of an NR2B subunit selective NMDA antagonist, which amount is effective in inhibiting neurological damage. This invention also provides a method of preventing primary hyperalgesia, secondary hyperalgesia, primary allodynia, secondary allodynia, or other pain caused by central sensitization, in a mammal, which method comprises administering to the mammal, prior to affliction with said pain, an amount of an NR2B subunit selective NMDA antagonist, which amount is effective in preventing said pain. |
申请公布号 |
ZA200108038(B) |
申请公布日期 |
2003.04.01 |
申请号 |
ZA20010008038 |
申请日期 |
2001.01.01 |
申请人 |
PFIZER PRODUCTS INC. |
发明人 |
CHENARD, BERTRAND, LEO;MENNITI, FRANK, SAMUEL;SALTARELLI, MARIO, DAVID, SCHNEIDER, ERIKA |
分类号 |
C07D211/52;A61K31/00;A61K31/05;A61K31/40;A61K31/439;A61K31/445;A61K31/451;A61K31/453;A61K45/00;A61K45/06;A61P3/10;A61P9/00;A61P9/10;A61P17/02;A61P17/06;A61P19/02;A61P19/08;A61P25/00;A61P25/02;A61P25/04;A61P25/06;A61P25/08;A61P27/16;A61P29/00;A61P31/12;A61P31/18;A61P31/22;A61P35/00;A61P37/06;A61P43/00;C07D407/04 |
主分类号 |
C07D211/52 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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