| 摘要 |
A 6-mercapto-cyclodextrin derivative of formula I, wherein: m is 0-7 and n is 1-8 and m+n = 7 or 8; R is (C1-6)alkylene, optionally substituted with 1-3 OH groups, or (CH2)o-phenylene-(CH2)p ; o and p are independently 0-4; X is COOH, CONHR1, NHCOR2, SO2OH, PO(OH)2, OCH2-CH2-O)q-H, OH or tetrazol-5-yl; R1 is H or (C1-3)alkyl; R2 is carboxyphenyl; q is 1-3; or pharmaceutically acceptable salts thereof; with the exclusion of 6-per-deoxy-6-per-(2-hydroxyethylthio)-â-cyclodextrin; 6-mono-deoxy-6-mono-(2-hydroxyethylthio)-â-cyclodextrin ; 6-per-deoxy-6-per-(2-hydroxyethylthio)-g-cyclodextrin; 6-per-deoxy-6-per-(carboxymethylthio)-â-cyclodextrin; 6-mono-deoxy-6-mono-(carboxymethylthio)-â-cyclodextrin; 6A,6B-dideoxy-6A,6B-bis [(o-carboxyphenyl)thio]-â- cyclodextrin; 6A,6B-dideoxy-6A,6B-bis (carboxymethylthiol)-â-cyclodextrin and 6-per-deoxy-6-per-(2, 3-dihydroxypropylthio)-â- cyclodextrin. These 6-mercapto-cyclodextrin derivatives are suitable for use in the reversal of drug-induced neuromuscular block caused by neuromuscular blocking agent (NMBA, also called a muscle relaxant).
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