| 摘要 |
<p>The invention relates to a method for the enantioselective preparation of the glycide ester (I) by (a) dihydroxylating a corresponding 3 phenyl cinnamic acid ester (II) by osmium (VIII) oxide catalysis in the presence of a Sharpless ligand and an oxidant to give a dihydroxy ester (III), (b) selectively converting the hydroxy function in the 2 position of the dihydroxy ester (III) to a leaving group, (c) intramolecularly substituting the leaving group by the hydroxy function in the 3 position to the glycide ester (I). In formulae (I), (II), and (III), R1 represents C1 C10 alkyl, aryl or arylalkyl, which can optionally be substituted, and R2 represents C1 C10 alkyl, aryl, arylalkyl, halogen, C1 C10 alkoxy, acyloxy or amide, which can be optionally substituted, and n is 0 to 5.</p> |
