| 发明名称 |
APPLICATION OF LEPTIN ANTAGONISTS FOR TREATMENT OF INSULIN RESISTANCE IN DIABETES MELLITUS TYPE II |
| 摘要 |
FIELD: medicine, endocrinology. SUBSTANCE: invention proposes pharmaceutical composition comprising antagonist of leptin. Invention relates also to method of treatment of diabetes mellitus II type using this composition, murine leptin fragment and method of its preparing. Invention ensures to reduce insulin-resistance by inhibition of leptin effect. EFFECT: improved method of treatment, valuable medicinal properties. 5 cl, 6 tbl |
| 申请公布号 |
RU2201249(C2) |
申请公布日期 |
2003.03.27 |
| 申请号 |
RU19990107759 |
申请日期 |
1997.09.15 |
| 申请人 |
KHEKHST AKTSIENGEZELL'SHAFT |
发明人 |
EHRTL' JOKHANN;PRAJBISH GERAL'D;MJULLER GJUNTER |
| 分类号 |
C12N15/09;A61K38/00;A61K38/17;A61K38/22;A61K45/00;A61P3/10;A61P5/50;C07K14/575;C07K16/26;C07K19/00;C12P21/02 |
主分类号 |
C12N15/09 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
