INHIBITORS OF RNASE P PROTEINS AS ANTIBACTERIAL COMPOUNDS

摘要

The present invention features compounds useful for inhibiting Rnase P activity. These compounds can be used as therapeutics for treating or preventing a variety of bacterial infections. The compounds belong to several classes including mono- and bis-guanylhydrazones, guanylhydrazone mimetics, and benzothiazolium compounds. Exemplary compounds are compounds of formula (I) Y-(NR')k-U1-(NR'')l-A-(NR<1>)m-U2-(NR<2>)n-Z with substituents as described herein.