HUMAN AND MOUSE beta -DEFENSINS, ANTIMICROBIAL PEPTIDES
摘要
The present invention employs an iterative application of BLAST and Hidden Markov Model (HMM) based searches which identified 34 beta -defensin genes in the human genome and 48 in the mouse genome. The present invention relates to novel antimicrobial peptides and derivatives thereof as well as the beta -defensin genes encoding the peptides. The invention further relates to methods of use of the peptides including a method of inhibiting microbial growth by administering an effective amount of the peptide alone or in combination with other antimicrobial agents antibiotics.
申请公布号
WO03024992(A2)
申请公布日期
2003.03.27
申请号
WO2002US30106
申请日期
2002.09.23
申请人
UNIVERSITY OF IOWA RESEARCH FOUNDATION;MCCRAY, PAUL, B., JR.;SCHUTTE, BRIAN, C.;JIA, HONG, PENG;CASAVANT, THOMAS, L.;WELCH, MICHAEL, J.
