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发明名称 CYTOKINE RECEPTOR
摘要 A crystalline composition comprising a crystal of the IL-6 receptor I chain is provided. Also provided are methods of using the crystal and related structural information to screen for and design compounds that interact with IL-6R, or variants thereof. Also provided are methods of modulating an IL-6 receptor comprising contacting the IL-6 receptor with a compound identified by the screening method of the invention.
申请公布号 WO03025017(A1) 申请公布日期 2003.03.27
申请号 WO2002AU01255 申请日期 2002.09.16
申请人 COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION;LUDWIG INSTITUTE FOR CANCER RESEARCH;WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH;VARGHESE, JOSEPH, NOOZHUMUTRY;SIMPSON, RICHARD, J;MORITZ, ROBERT, LORENZ;LOU, MEIZHEN;JI, HONG;BRANSON, KIM, MATTHEW;SMITH, BRIAN, JOHN 发明人 VARGHESE, JOSEPH, NOOZHUMUTRY;SIMPSON, RICHARD, J;MORITZ, ROBERT, LORENZ;LOU, MEIZHEN;JI, HONG;BRANSON, KIM, MATTHEW;SMITH, BRIAN, JOHN
分类号 G01N33/15;A61K31/00;A61K31/122;A61K31/136;A61K31/166;A61K31/167;A61K31/185;A61K31/19;A61K31/325;A61K31/343;A61K31/352;A61K31/381;A61K31/4035;A61K31/407;A61K31/428;A61K31/435;A61K31/437;A61K31/4375;A61K31/4709;A61K31/472;A61K31/4741;A61K31/4745;A61K31/519;A61K31/522;A61K31/704;A61K45/00;A61P13/12;A61P17/00;A61P17/06;A61P19/02;A61P19/10;A61P29/00;A61P31/04;A61P31/18;A61P35/00;A61P37/00;A61P43/00;C07D203/18;C07D209/48;C07D217/06;C07D219/04;C07D219/12;C07D277/60;C07D307/77;C07D311/30;C07D311/62;C07D333/48;C07D401/12;C07D473/34;C07D487/04;C07D487/06;C07D491/18;C07D498/04;C07D515/22;C07D519/00;C07H15/20;C07K14/705;C07K14/715;G06F19/00;G06F19/16 主分类号 G01N33/15
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