MODIFIED CLOSTRIDIAL NEUROTOXINS WITH ALTERED BIOLOGICAL PERSISTENCE

摘要

The present invention discloses modified neurotoxins with altered biological persistence. In one embodiment, the modified neurotoxins are derived from Clostridial botulinum toxins and the modification involves one or more secondary modification sites. In a BoNT/E (Botilunum Toxin serotype E) derivative, the N-terminal myristylation site GVDIAY is fused to position 15 of the BoNT/E light chain. In a BoNT/A derivative the N-terminal myristylation site GLEVSF at position 254 is deleted. Such modified neurotoxins may be employed in treating various conditions, including but not limited to muscular disorders, hiperhidrosis, and pain.