发明名称 |
Method for the manufacture of Anagrelide |
摘要 |
Methods are provided for making Anagrelide base from 2,3-dichlorobenzaldehyde. A method is also provided for making an intermediate compound ethyl N-(2,3-dichloro-6-nitrobenzyl)glycine from 2,3-dichlorobenzaldehyde and for reducing the glycine compound using either SnCl2 or a specially defined catalyst. A cyclization method to form Anagrelide base from the corresponding iminoquinazoline compound is further provided.
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申请公布号 |
US2003060630(A1) |
申请公布日期 |
2003.03.27 |
申请号 |
US20020134088 |
申请日期 |
2002.04.25 |
申请人 |
SHIRE US INC. |
发明人 |
LANG PHILIP C.;SPENCER ROXANNE P.;YEH WEN-LUNG;ROTH MICHAEL JOSEPH |
分类号 |
C07C205/12;C07C205/26;C07C205/44;C07C227/04;C07C227/16;C07C229/16;C07D487/04;(IPC1-7):C07D487/14 |
主分类号 |
C07C205/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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