发明名称 |
HYDROXYEICOSENOIC ACID ANALOGS |
摘要 |
A hydroxyeicosenoic acid analog represented by the following Formula (I), th e bond .ident. represents a cis-vinylene group or an ethynylene group; Y represents CH2, O or S(O)p wherein p is 0, 1 or 2; m represents an integer o f 1 to 4 inclusive; n represents an integer of 0 to 3 inclusive; the sum of m and n is an integer of 3 to 7 inclusive; R1 represents a C1-4 alkyl group or a C3-8 cycloalkyl group; R2 represents a hydrogen atom or a methyl group; R3 represents COR4, a nitrile group, a halogen atom, a tetrazole group or a thiazolidinedione group; R4 represents OR6, NHR6, N(OH)R6, NHSO2R5, glycerol or functionalized glycerols; R5 represents a C1-15 alkyl group, a C6-10 aryl group or a C7-14 aryl group substituted with alkyl groups, halogens or amino groups; R6 represents a hydrogen, a C1-10 alkyl group or a C1-10 alkyl group substituted with a hydroxyl group, or a pharmaceutically acceptable salt or hydrate thereof. The compounds of the present invention are useful as an elastase release inhibitor.
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申请公布号 |
CA2460263(A1) |
申请公布日期 |
2003.03.27 |
申请号 |
CA20022460263 |
申请日期 |
2002.09.09 |
申请人 |
TAISHO PHARMACEUTICAL CO., LTD.;BOARD OF REGENTS, THE UNIVERSITY OF TEXAS |
发明人 |
OKUYAMA, SHIGERU;TODA, YOSHIHISA;ONO, NAOYA;CHONAN, TOMOMICHI;HIRANO, HITOMI;MIYATA, NORIYUKI;TANAMI, TOHRU;FALCK, JOHN R. |
分类号 |
C07D277/20;A61K31/047;A61K31/08;A61K31/16;A61K31/18;A61K31/185;A61K31/201;A61K31/231;A61K31/275;A61K31/41;A61K31/426;A61P1/02;A61P1/04;A61P1/16;A61P1/18;A61P7/02;A61P9/00;A61P9/10;A61P11/00;A61P11/06;A61P11/08;A61P13/12;A61P15/00;A61P15/06;A61P17/02;A61P17/06;A61P19/00;A61P19/02;A61P27/02;A61P29/00;A61P31/00;A61P31/04;A61P37/02;A61P37/06;A61P43/00;C07C33/04;C07C33/044;C07C33/42;C07C59/01;C07C59/42;C07C59/46;C07C59/60;C07C69/708;C07C69/732;C07C235/28;C07C255/15;C07C255/16;C07C259/06;C07C309/08;C07C309/10;C07C309/20;C07C309/23;C07C309/24;C07C309/68;C07C311/04;C07C311/17;C07C311/51;C07C317/44;C07C323/52;C07C323/66;C07D257/04;C07D277/34;(IPC1-7):C07C59/00;C07C255/00;C07D277/00;A61K31/42;A61K31/425 |
主分类号 |
C07D277/20 |
代理机构 |
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