COMPOSITIONS AND METHODS FOR LABELING OLIGONUCLEOTIDES

摘要

A novel method for the labeling of oligonucleotides which results in the economical synthesis of 5' labeled molecules. A set of suitably protected and carefully selected set of amino linkers, a modified deprotination/cleavage protocol and standard coupling methodologies to are used to allow for the convergent synthesis of any number of labeled oligonucleotides.