6,7-DIHYDRO-5H-PYRAZOLO[1,2-A]PYRAZOL-1-ONES WHICH CONTROL INFLAMMATORY CYTOKINES

摘要

The present invention relates to compound which are capable of preventing the extracellular release of inflammatory cytokines, said compounds, including all enantiomeric and diasteriomeric forms and pharmaceutically acceptable salts thereof, have the formula I: wherein R comprises ethers or amines R1 is: a substituted or unsubstituted aryl or b substituted or unsubstituted heteroaryl each R?2¿ unit is independently selected from the group consisting of: a hydrogen b -CH¿2?¿j?OCH¿2?nR?8¿ c -CH¿2?¿j?NR?9a¿R?9b¿ d -CH¿2?¿j?CO¿2?R?10¿ e -CH¿2?¿j?OCO?2¿R?10¿ f -CH¿2?¿j?CONR?10¿¿2? g -CH¿2?¿j?OCONR?10¿¿2? h two R?2¿ units can be taken together to form a carbonyl unit i and mixtures thereof R?8¿, R?9a¿, R?9b¿, and R?10¿ are each independently hydrogen, C¿1?-C¿4? alkyl, and mixtures thereof R?9a¿ and R?9b¿ can be taken together to form a carbocyclic or heterocyclic ring comprising from 3 to 7 atoms two R?10¿ units can be take together to form a carbocyclic or heterocyclic ring comprising from 3 to 7 atoms j is an index from 0 to 5, n is an index from 0 to 5Z is O, S, NR?11¿, or NOR?11¿ R?11¿ is hydrogen or C¿1?-C¿4? alkyl.