发明名称 |
CONTROLLED RELEASE SOLID DISPERSIONS |
摘要 |
A controlled release pharmaceutical composition for oral use comprising a solid dispersion of: i) at least one therapeutically, prophylactically and/or diagnostically active substance, which at least partially is in an amorphous form, ii) a pharmaceutically acceptable polymer that has plasticizing properties, and iii) optionally, a stabilizing agent, the at least one active substance having a limited water solubility, and the composition being designed to release the active substance with a substantially zero order release. The polymer is typically a polyethylene glycol and/or polyethylene oxide having a molecular weight of at least about 20,000 in crystalline and/or amorphous form or a mixture of such polymers, and the active substance is typically carvedilol. The composition may comprise a coated matrix, the coating comprising a first cellulose derivative which is substantially insoluble in the aqueous medium, and at least one of a) a second cellulose derivative which is soluble or dispersible in water, b) a plasticizer, and c) a filler.
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申请公布号 |
WO03024426(A1) |
申请公布日期 |
2003.03.27 |
申请号 |
WO2002DK00621 |
申请日期 |
2002.09.23 |
申请人 |
EGALET A/S;FISCHER, GINA;BAR-SHALOM, DANIEL;SLOT, LILLIAN;LADEMANN, ANNE-MARIE;JENSEN, CHRISTINE |
发明人 |
FISCHER, GINA;BAR-SHALOM, DANIEL;SLOT, LILLIAN;LADEMANN, ANNE-MARIE;JENSEN, CHRISTINE |
分类号 |
A61K9/00;A61K9/20;A61K9/22;A61K9/28;A61K31/403;(IPC1-7):A61K9/16 |
主分类号 |
A61K9/00 |
代理机构 |
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地址 |
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