A METHOD TO INCORPORATE N-(4-HYDROXYPHENYL) RETINAMIDE IN LIPOSOMES
摘要
Disclosed herein are simple and unique methods of methods of preparing liposomal compositions of N-(4-hydroxyphenyl) retinamide (4HPR) and/or other retinoids. Also disclosed are liposomal 4HPR compositions prepared by such methods and use of such compositions in the treatment of diseases, such as breast cancer. This invention further provides methods for improving the efficacy of N-(4-hydroxyphenyl) retinamide (4HPR) as a chemopreventive agent in the presence of agents that potentiates its ability increase the expression of inducible nitric oxide synthase (iNOS), and NO production in cells.
申请公布号
WO0232413(A3)
申请公布日期
2003.03.27
申请号
WO2001US32310
申请日期
2001.10.17
申请人
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM;LOPEZ-BERESTEIN, GABRIEL;TARI, ANA, MARIA;LIM, SOO-JEONG