| 摘要 |
<p>It is intended to provide an oxidation stress inhibitor containing as the active ingredient a pyrazolone derivative represented by the formula (I) as defined in the description or its pharmaceutically acceptable salt; and a method of measuring oxidation stress characterized by using a monounsaturated fatty acid, ubiquinone-10 or cholesterol ester hydroperoxide in the plasma as a marker, a clinical examination method a method of evaluating a drug. The above-mentioned drug is useful as a preventive/a remedy for various oxidation stress diseases (for example, ischemic diseases and various diseases depending thereon, namely, cerebrovascular diseases such as brain infarction and brain attack, brain hypofunction and vascular dementia caused thereby, various brain diseases in association with aging such as cerebrovascular tissue lesion, various peripheral circulatory disorders based on cardiomuscular ischemia such as cardiomuscular infarction and heart failure, liver failure, and diabetes). The above-mentioned method of measuring oxidation stress makes it possible to accurately and quantitatively measure oxidation stress, which makes it applicable to clinical examinations and evaluation of drugs.</p> |
