CELL AND TISSUE CULTURE MODELING DEVICE AND APPARATUS AND METHOD OF USING SAME

摘要

A cell and tissue culture modeling device (10) comprising a housing (15) having an interior chamber (57), an inlet port (20) in fluid communication with the internal chamber (57), an outlet port (25) in fluid communication with the internal chamber (57), a plurality of hollow fibers (60) disposed within the interior chamber (57) and traversing the length of the housing (15) between the inlet port (20) and the outlet port (25). Each of the plurality of hollow fibers (60) has an interior (70) defining an intracapillary space (75) and the interior chamber (57) defines an extracapillary space (67) unoccupied by the plurality of hollow fibers (60). To access the extracapillary space of the device, a portion (55) of the housing is removable. The device can be used to conduct permeability, drug efficacy, and gene expression studies.