INHIBITION OF STRESS ACTIVATED PROTEIN KINASE (SAPK) PATHWAY AND SENSITIZATION OF CELLS TO CANCER THERAPIES

摘要

The present invention provides compositions that can be administered to an individual and inhibit a stress activated protein kinase pathway. The invention also provides methods of increasing the sensitivity of cancer cells to a cancer therapy by contacting the cancer cells with a stress activated protein kinase pathway inhibitor. The invention further provides methods of reducing the severity of cancer in a patient by administering to the patients a stress activated protein kinase pathway inhibitor and treating the patient with a conventional cancer therapy.