Prodrugs of non-steroidal anti-inflammatory and carboxylic acid containing compounds

摘要

Compounds of the formula: RC(O)O-spacer-OC(O)R', wherein (i) RC(O)- is the acyl residue of an NSAID or other pharmaceutically active agent bearing a carboxylic acid function, (ii) spacer is Cn alkyl, (iii) n is from 1 to 6, and (iv) R' is substituted or unsubstituted heteroaryl or heterocycle, and pharmaceutical compositions thereof.