发明名称 |
BRAIN EXPRESSED CAP-2 GENE AND PROTEIN ASSOCIATED WITH BIPOLAR DISORDER |
摘要 |
We previously identified 18q21.33-q23 as a candidate region for bipolar (BP) disorder and constructed a yeast artificial chromosome (YAC) contig map. In a next step we isolated and analysed all CAG/CTG repeats from this region and excluded them from involvement in BP disorder. Here, in the process of identifying all CCG/CGG repeats from the region, we found a cluster of 6 gen es encoding for serpins. For one of them, CAP2 located at 18q21.3, a mutation analysis was performed. Analysis of the thus identified single nucleotide polymorphisms (six in total) revealed a statistically significant associatio n of SNP c.942G>T with BP disorder. It is thus an object of the present invention to provide a method of diagnosing BP or susceptibility to BP in an individual which method comprises determining, in a sample from the individual, the single nucleotide polymorphism in the CAP2 gene of the individual, and determining the status of the individual by reference to polymorphism in the CAP2 gene.
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申请公布号 |
CA2458303(A1) |
申请公布日期 |
2003.03.27 |
申请号 |
CA20022458303 |
申请日期 |
2002.09.17 |
申请人 |
JANSSEN PHARMACEUTICA N.V. |
发明人 |
VAN BROECKHOVEN, CHRISTINE;DEL-FAVERO, JURGEN PETER LODE |
分类号 |
G01N33/53;C07K14/81;C12N15/09;C12N15/15;C12Q1/68;G01N33/566;(IPC1-7):C12Q1/68 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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