发明名称 |
N-aryl(thio)anthranilic acid amide derivatives, their preparation and their use as VEGF receptor tyrosine kinase inhibitors. |
摘要 |
Described are compunds of formula (I), wherein W is O or S; X is NR8; Y is CR9R10-(CH2)n wherein R9 and R10 are independently of each other hydrogen or lower alkyl, and n is an integer of from and including 0 to and including 3; or Y is SO2; R1 is aryl; R2 is a bicyclic heteroaryl group comprising one ring nitrogen atom with the exception that R2 cannot represent 2-phthalimidyl; any of R3, R4, R5 and R6, independently of the other, is H or a substituent other than hydrogen; and R7 and R8, independently of each other, are H or lower alkyl; or a N-oxide or a pharmaceutically acceptable salt thereof for the preparation of a pharmaceutical product for the treatment of a neoplastic disease which responds to an inhibition of the VEGF receptor tyrosine kinase activity. The compounds of formula (I) can be used for the treatment e.g. of a neoplastic disease, such as a tumor disease, of retinopathy and age-related macular degeneration. |
申请公布号 |
ZA200103290(B) |
申请公布日期 |
2003.03.26 |
申请号 |
ZA20010003290 |
申请日期 |
2001.04.23 |
申请人 |
NOVARTIS AG, SCHERING AKTIENGESELLSCHAFT |
发明人 |
KARL-HEINZ ALTMANN;PASCAL FURET;WOOD, JEANETTE, MARJORIE;FRANCESCO HOFMANN;ANDREAS HUTH;DIETER SEIDELMANN;MARTIN HABEREY;GUIDO BOLD;PAUL WILLIAM MANLEY;STEFANO FERRARI;JUERGEN MESTAN;MARTIN KRUEGER;ANDREAS MENRAD;KARL-HEINZ THIERAUCH |
分类号 |
C07D233/64;A61K;A61K31/00;A61K31/166;A61K31/167;A61K31/415;A61K31/417;A61K31/44;A61K31/4409;A61K31/443;A61K31/444;A61K31/47;A61K31/4745;A61K31/497;A61K31/505;A61P;A61P17/00;A61P27/02;A61P35/00;A61P43/00;C07C;C07C223/02;C07C237/30;C07C317/26;C07D;C07D211/22;C07D213/04;C07D213/38;C07D213/40;C07D213/61;C07D213/64;C07D213/89;C07D215/12;C07D215/14;C07D215/36;C07D215/58;C07D233/54;C07D265/26;C07D401/12;C07D401/14;C07D405/12;C07D407/12;C07D409/12;C07D413/12;C07D471/02 |
主分类号 |
C07D233/64 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|