The invention provides a process for the preparation of a pharmaceutical composition comprising an aqueous dispersion of gas-containing vesicles the membranes whereof comprise an amphiphilic membrane-forming material, said process comprising: (i) generating a liquid dispersion of gas-containing vesicles from a mixture comprising an amphiphilic membrane forming material; (ii) lyophilizing a liquid dispersion of said gas-containing vesicles; (iii) reconstituting the lyophilized product of step (ii) with a sterile aqueous liquid to produce an aqueous dispersion of gas-containing vesicles; and (iv) treating the aqueous dispersion product of step (iii) or the lyophilized product of step (ii) to produce a substantially aggregate-free sterile aqueous dispersion of gas-containing vesicles.
申请公布号
EP1007102(B1)
申请公布日期
2003.03.26
申请号
EP19980939753
申请日期
1998.08.19
申请人
AMERSHAM HEALTH AS
发明人
HENRIKSEN, INGRID;KASPARKOVA, VERA;ANDERSEN, ARNFINN;FAHLVIK, ANNE, KJERSTI;ODEGARDSTUEN, LIV, INGRID