Composition useful in the treatment of pathologies associated with e.g. hyperglycemia, diabetes, dyslipidemia, obesity, arterial hypertension, neuropathies, and nephropathies, comprises oxamate derivatives

摘要

Composition comprises oxamate derivatives containing substituted nitrogen heterocycle, their tautomeric forms, enantiomers, diastereoisomers, epimers or salts. Composition comprises oxamate derivatives containing substituted nitrogen heterocycle of formula (I), their tautomeric forms, enantiomers, diastereoisomers, epimers or salts. R, R<1>-R<4> = H or 1-3C alkyl; X = O, S, CR<5>R<5>' or NR<6>; R<5>, R<5>' = H, OH, 1-5C alkyl, CO-R<7> or 6-14C aryl (optionally substituted); R<6> = 1-10C alkyl, 2-10C alkene, 6-14C aryl, 5-8 membered heterocyclic radical (comprising at least one of O, N or S) (all optionally substituted), H, R<8>-(CH2)m-C(=O)-(CH2)n or sulfonyl (optionally substituted by at least one T); T = 1-20C alkyl, perfluoroalkyl, 6-14C aryl, 5-8 membered cycloalkyl or 5-8 membered heterocyclic (comprising at least one O, N or S) or styryl (all optionally substituted); m, n = 0 or 1; R<7> = OH, 1-5C alkyl, 1-5C alkoxy, 6-14C aryl or 6-14C aryloxy; R<8> = 2-5C alkene, 5-8 membered cycloalkyl or cycloalkoxy, 6-14C aryl, 6-14C aryloxy, 5-8 membered heterocyclic or heteroaryloxy (containing at least one O, N or S) (all optionally substituted), H, OH, 1-5C alkoxy, 1-5C alkyl or NR<9>R'<9>; R<9>, R'<9> = 1-5C alkyl, 6-14C aryl (both optionally substituted), H or COR<7>; R<9>+R'<9> = 3-10 membered ring optionally containing at least one O, N or S. Provided that when X represents NR<6> then R<1> and R<6> can together form a 3-10 membered ring optionally containing at least one O, N or S. Independent claims are also included for: (1) new oxamate derivatives of formula (I) (provided that when X is NR<6>, then R<6> is other than phenyl (substituted in the para position by a methyl and in the meta position by a halogen), benzyl or beta -phenethyl radical; when X is O then R<1>-R<4> other than H; and when X is CR<5>R'<5> then R<1>-R<5> and R'<5> are other than H); and (2) preparation of (I).