CRYSTAL STRUCTURE OF INTERLEUKIN-22 AND USES THEREOF

摘要

This invention provides the three dimensional structure of human IL-22 and recombinant human IL-22 with mutations in the receptor binding regions and the dimerization interface and nucleic acid molecule encoding same. This invention also relates to methods of using pharmaceutical formulations and mimetics of the recominant IL-22 and to methods for generating mutants based on the crystalline structure of IL-22.