发明名称 |
DISTINGUISHING AGONISTS, ANTAGONISTS, AND INVERSE AGONISTS USING PWR |
摘要 |
The biophysical consequences of inverse agonist binding to membrane-bound receptors are characterized by PWR (1). An inverse agonist (TMT-Tic) produces membrane thickness, mass density and refractive index anisotropy increases which are similar to, but considerably smaller than, those generated by agonists. Thus, a third conformational state is produced by this ligand, different from those formed by agonists and antagonists, providing a method of distinguishing between agonist, antagonist, and inverse antagonist ligands of membrane-bound receptors, such as G protein-coupled receptors, utilizing PWR. |
申请公布号 |
WO03023361(A2) |
申请公布日期 |
2003.03.20 |
申请号 |
WO2002US28766 |
申请日期 |
2002.09.09 |
申请人 |
THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA;HRUBY, VICTOR, J.;TOLLIN, GORDON;SALAMON, ZDZISLAW;COWELL, SCOTT |
发明人 |
HRUBY, VICTOR, J.;TOLLIN, GORDON;SALAMON, ZDZISLAW;COWELL, SCOTT |
分类号 |
G01N33/543;G01N33/566 |
主分类号 |
G01N33/543 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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