发明名称 |
HEMOCYANIN NUCLEIC ACIDS AND POLYPEPTIDES AND RELATED VECTORS, FUSION PROTEINS, CONJUGATES, CELLS AND METHODS OF USE |
摘要 |
An isolated or purified nucleic acid molecule consisting essentially of a nucleotide sequence encoding KLH or a fragment thereof, as well as an isolated or purified nucleic acid molecule consisting essentially of a nucleotide sequence complementary thereto; a vector comprising such a nucleic acid, optionally as part of an encoded fusion protein when the nucleic acid encodes KLH or fragment thereof; a cell comprising and expressing an above-described nucleic acid, optionally in the form of a vector; an isolated or purified polypeptide molecule consisting essentially of an amino acid sequence encoding KLH-1, KLH-2, or a fragment of either of the foregoing, as well as a conjugate or fusion protein comprising the same and a therapeutically or prophylactically active agent, and related compositions; a method of treating cancer, pathogenic infection, and high blood pressure in a mammal; methods of stimulating an immune response in a mammal; a method of identifying an immunogenic portion of KLH, and an isolated or purified nucleic acid molecule consisting essentially of a nucleotide sequence encoding the leader sequence of KLH-1 or KLH-2, optionally coupled 5' to an isolated or purified nucleic acid molecule encoding a polypeptide or protein, in which case the nucleic acid is optionally in the form of a vector, as well as a eukaryotic cell comprising and expressing same. |
申请公布号 |
WO03023006(A2) |
申请公布日期 |
2003.03.20 |
申请号 |
WO2002US28581 |
申请日期 |
2002.09.06 |
申请人 |
PIERCE BIOTECHNOLOGY, INC.;FREY, MARK, J.;STRACHAN, ELIZABETH, ANN |
发明人 |
FREY, MARK, J.;STRACHAN, ELIZABETH, ANN |
分类号 |
C07K14/435;C12N5/02 |
主分类号 |
C07K14/435 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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