发明名称 |
Novel 3' terminal sequence of hepatitis C virus genome and diagnostic and therapeutic uses thereof |
摘要 |
The invention relates to the discovery of a novel RNA sequence at the 3' terminal sequence of hepatitis C virus (HCV) genome RNA. Included in the invention are the 3' sequence, its complement, and their use for nucleic-acid based diagnostics and for developing and evaluating novel anti-HCV therapies. This sequence element, which is conserved among HCV genotypes, is likely to be essential for viral replication, and required for construction of full-length HCV cDNA clones capable of yielding infectious RNA, progeny virus or replication-competent HCV replicons. Such functional clones are useful tools for evaluation of therapeutic approaches and as substrates for developing candidate attenuated or inactivated HCV derivatives for vaccination against HCV.
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申请公布号 |
US2003054341(A1) |
申请公布日期 |
2003.03.20 |
申请号 |
US20020158314 |
申请日期 |
2002.05.30 |
申请人 |
RICE CHARLES M.;KOLYKHALOV ALEXANDER A. |
发明人 |
RICE CHARLES M.;KOLYKHALOV ALEXANDER A. |
分类号 |
G01N33/50;A61K31/00;A61K38/00;A61K38/21;A61K39/00;A61K45/00;A61K48/00;A61P1/00;A61P1/16;A61P31/00;A61P31/12;A61P31/20;A61P35/00;C07K14/18;C12N5/08;C12N5/10;C12N7/00;C12N15/09;C12Q1/70;G01N33/566;G01N33/576;(IPC1-7):C12Q1/70;C12Q1/68;C07H21/04 |
主分类号 |
G01N33/50 |
代理机构 |
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代理人 |
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地址 |
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